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Firstly, the hole in the top right portrays same image of my Alfred Nobel's laboratory up in the sky. I have shown similar, almost same picture as the image above by using simple long rectangular cubism to illustrate Nobel's quote "Thousand Ideas." By having a hole inside the solid rectangular cubism describes that it needs deeper thinking to come up with thousands of ideas. And your thinking comes from deep inside your brain through the neuron like a hollow cube.
Secondly, the subtraction of cube shapes from solid area also corresponds to Keith Campbell's laboratory. Campbell's lab has strong subtraction of two cube shape with solid cube shape in the centre referring to the image above with different angled hard edged cube shapes with strong solid cube structure shapes being dormant by the tone as well.
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